AOAC INTERNATIONAL (AOAC) invites method developers to submit methods for First Action consideration and possible evaluation through the AOAC Official MethodsTM program. Prospective methods must be able to quantitatively analyze 35 pyrrolizidine alkaloids (PAs) by chromatographic separation with mass spectrometric (MS) detection in teas, herbal infusions, dried herbs, seed spices, honey, and botanical dietary supplements and ingredients, meeting the recently approved Standard Method Performance Requirement® (AOAC SMPR®2023.002).
An eligible method must meet the various parameters outlined in the SMPR® and must be reliable, repeatable, and ultimately reproducible when used by trained analysts. The intent is to establish an official method for surveillance and monitoring. Reference the SMPR® for definitions and the proposed method validation requirements for parameters such as limit of quantification, recovery, repeatability and reproducibility, system suitability, and reference materials.
Interested method developers must provide their method and accompanying validation data (at minimum from a single-laboratory validation study) demonstrating that the method can meet the performance requirements.
Submit your method(s) for First Action status consideration (email submissions will not be accepted).
For general information or comments on the Official MethodsTM program please contact Constance Bahr.